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A serum B12 level test and, ideally, a methylmalonic acid (MMA) test should precede any B12 injection recommendation
Watch for cloudiness, which indicates bacterial contamination or protein aggregation
The topical provides a daily surface-level dose to the face and neck
The safe default for any new combination is to introduce one active at a time, watch for irritation, and separate anything acidic or potent into a different routine
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